Mark Hughes marked his return to Southampton with a 2-0 victory over Wigan to seal their second Wembley outing in two years.
Pierre-Emile Hojbjerg and Cedric Soares scored the goals against the League One side as Saints make their first Semi Final appearance since 2003.
After a difficult first half where the hosts pressured the Saints goal on a number of occasions, it was the visitors to take their chances which made the difference in the game.
Wigan who had knocked out high flying Manchester City in the previous round showed glimpses of causing yet another upset through the likes of Will Grigg and Nick Powell, but nothing came to prevail.
Hojbjerg was the man to put the Premier League side ahead as he touched home from Dusan Tadic’s corner on the 62 minute.
There was a lifeline when Saints were just one-nil up as Manolo Gabbiadini’s penalty was saved by Christian Walton in the Latics goal.
But it was in the first minute of added time where Nathan Redmond’s attempted ball was half blocked and found it’s way into the path of Soares.
All that was left for him to do was to use his pace as the right back knocked it past Dan Burn, leading him through one-on-one with Walton as he neatly finished for his first goal in red and white.
There were 4,000 visiting fans there to see the historic victory in Hughes’ first game in charge and back at Southampton.
Next is the task for Hughes and his men to take on one of his old clubs, after being drawn with current Premier League Champions Chelsea at Wembley on the 21/22 April.